Open AccessThermodynamic System Drift in Protein Evolution
Author(s) -
Kathryn M. Hart,
Michael J. Harms,
Bryan H. Thurtle-Schmidt,
Carolyn Elya,
Joseph W. Thornton,
Susan Marqusee
Publication year - 2014
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001994
Subject(s) - biology , evolutionary biology , protein evolution , computational biology , genetics , gene
Tracking the evolution of thermostability in resurrected ancestors of a heat-tolerant extremophile protein and its less heat tolerant Escherichia coli homologue shows how thermostability has probably explored different mechanisms of protein stabilization over evolutionary time.
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