Open AccessDEAD-Box Helicase Proteins Disrupt RNA Tertiary Structure Through Helix Capture
Author(s) -
Cynthia Pan,
Jeffrey P. Potratz,
Brian Can,
Zachary Booth Simpson,
Jessica L. Ziehr,
Pilar Tijerina,
Rick Russell
Publication year - 2014
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001981
Subject(s) - biology , rna helicase a , helicase , rna , dead box , protein tertiary structure , helix (gastropod) , computational biology , nucleic acid structure , microbiology and biotechnology , genetics , biochemistry , gene , ecology , snail
Single-molecule fluorescence experiments reveal how DEAD-box proteins unfold structured RNAs to promote conformational transitions and refolding to the native functional state.
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