Cell Fate Regulation Governed by a Repurposed Bacterial Histidine Kinase | Zendy

W. Seth Childers | Zendy; Qingping Xu | Zendy; Thomas H. Mann | Zendy; Irimpan I. Mathews | Zendy; Jimmy A. Blair | Zendy; Ashley M. Deacon | Zendy; Lucy Shapiro | Zendy

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Cell Fate Regulation Governed by a Repurposed Bacterial Histidine Kinase

Author(s) -

W. Seth Childers,

Qingping Xu,

Thomas H. Mann,

Irimpan I. Mathews,

Jimmy A. Blair,

Ashley M. Deacon,

Lucy Shapiro

Publication year - 2014

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001979

Subject(s) - histidine kinase , biology , response regulator , caulobacter crescentus , histidine , microbiology and biotechnology , kinase , allosteric regulation , transcription factor , phosphorylation , two component regulatory system , cell fate determination , biochemistry , regulator , mutant , cell , cell cycle , receptor , amino acid , gene

The pathway that regulates asymmetric cell division in Caulobacter involves a signaling kinase whose catalytic output domain has been repurposed as an input sensor of the phosphorylation state of the response regulator – a reversal of the conventional direction of information flow; this allows wiring of simple linear signaling pathways into complex eukaryote-like networks.

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