Integration of Signals along Orthogonal Axes of the Vertebrate Neural Tube Controls Progenitor Competence and Increases Cell Diversity | Zendy

Noriaki Sasai | Zendy; Eva Kutějová | Zendy; James Briscoe | Zendy

Open Access

Integration of Signals along Orthogonal Axes of the Vertebrate Neural Tube Controls Progenitor Competence and Increases Cell Diversity

Author(s) -

Noriaki Sasai,

Eva Kutějová,

James Briscoe

Publication year - 2014

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001907

Subject(s) - neural tube , biology , neural crest , progenitor cell , floor plate , microbiology and biotechnology , neural plate , fibroblast growth factor , morphogen , transcription factor , sonic hedgehog , cell type , anatomy , bone morphogenetic protein , embryo , signal transduction , neuroscience , cell , genetics , receptor , stem cell , gene

FGF gates competence to generate Floor Plate and Neural Crest in response to Shh and BMP signals by controlling expression of the transcription factor Nkx1.2.

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