The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity | Zendy

Cendrine Tourette | Zendy; Francesca Farina | Zendy; Rafael P. VázquezManrique | Zendy; Anne-Marie Orfila | Zendy; Jessica Voisin | Zendy; Sonia L. Hernandez | Zendy; Nicolas Offner | Zendy; J. Alex Parker | Zendy; Sophie Menet | Zendy; Jinho Kim | Zendy; Jungmok Lyu | Zendy; Si Ho Choi | Zendy; Kerry Cormier | Zendy; Christina K. Edgerly | Zendy; Olivia L. Bordiuk | Zendy; Karen Smith | Zendy; Anne Louise | Zendy; Michael M. Halford | Zendy; Steven A. Stacker | Zendy; JeanPhilippe Vert | Zendy; Robert J. Ferrante | Zendy; Wange Lu | Zendy; Christian Néri | Zendy

Open Access

The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

Author(s) -

Cendrine Tourette,

Francesca Farina,

Rafael P. VázquezManrique,

Anne-Marie Orfila,

Jessica Voisin,

Sonia L. Hernandez,

Nicolas Offner,

J. Alex Parker,

Sophie Menet,

Jinho Kim,

Jungmok Lyu,

Si Ho Choi,

Kerry Cormier,

Christina K. Edgerly,

Olivia L. Bordiuk,

Karen Smith,

Anne Louise,

Michael M. Halford,

Steven A. Stacker,

JeanPhilippe Vert,

Robert J. Ferrante,

Wange Lu,

Christian Néri

Publication year - 2014

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001895

Subject(s) - huntingtin , neuroprotection , microbiology and biotechnology , wnt signaling pathway , mutant , biology , huntingtin protein , programmed cell death , signal transduction , biochemistry , neuroscience , apoptosis , gene

A study of Huntington's disease reveals that neurons might fail to cope with maintaining their function during the pre-symptomatic, pathogenic phases of HD, possibly due to the early repression of key longevity-promoting transcription factors by abnormal developmental signaling.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research