Large-Scale Determination of Sequence, Structure, and Function Relationships in Cytosolic Glutathione Transferases across the Biosphere | Zendy

Susan T. Mashiyama | Zendy; M. Merced Malabanan | Zendy; Eyal Akiva | Zendy; R. Bhosle | Zendy; Megan C. Branch | Zendy; B. Hillerich | Zendy; Kevin L. Jagessar | Zendy; Jungwook Kim | Zendy; Y. Patskovsky | Zendy; R.D. Seidel | Zendy; Mark B. Stead | Zendy; R. Toro | Zendy; M.W. Vetting | Zendy; Steven C. Almo | Zendy; Richard N. Armstrong | Zendy; Patricia C. Babbitt | Zendy

Open Access

Large-Scale Determination of Sequence, Structure, and Function Relationships in Cytosolic Glutathione Transferases across the Biosphere

Author(s) -

Susan T. Mashiyama,

M. Merced Malabanan,

Eyal Akiva,

R. Bhosle,

Megan C. Branch,

B. Hillerich,

Kevin L. Jagessar,

Jungwook Kim,

Y. Patskovsky,

R.D. Seidel,

Mark B. Stead,

R. Toro,

M.W. Vetting,

Steven C. Almo,

Richard N. Armstrong,

Patricia C. Babbitt

Publication year - 2014

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001843

Subject(s) - biology , superfamily , function (biology) , computational biology , sequence alignment , structural similarity , genetics , peptide sequence , similarity (geometry) , protein sequencing , evolutionary biology , biochemistry , gene , computer science , artificial intelligence , image (mathematics)

Global networks of the cytosolic glutathione S-transferases illuminate sequence-structure-function relationships across more than 13,000 members of this superfamily, including experimental confirmation of enzymatic activity for 82 members and new crystal structures for 27.

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