Bulge, Bubble, and Y: How an RNA Exonuclease Repairs DNA, in Detail | Zendy

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Bulge, Bubble, and Y: How an RNA Exonuclease Repairs DNA, in Detail

Author(s) -

Richard Robinson

Publication year - 2014

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001804

Subject(s) - biology , dna , bulge , genetics , exonuclease , exonuclease iii , rna , computational biology , gene , physics , dna polymerase , astrophysics , stars , escherichia coli

For a cell, it's not so much death or taxes, but damage to its DNA, that is inevitable. Chemicals, radiation, and ultraviolet light all take their toll, disrupting the double helix and leaving dangerous chaos in their wake. The genome in virtually every cell in every organism suffers such damage multiple times over its lifespan. Left unrepaired, such disruptions would quickly leave the cell either unable to survive, or perhaps unable to check its own growth. Many tumors get their start when a damaged gene is unsuccessfully repaired.

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