Cecum Lymph Node Dendritic Cells Harbor Slow-Growing Bacteria Phenotypically Tolerant to Antibiotic Treatment | Zendy

Patrick Kaiser | Zendy; Roland R. Regoes | Zendy; Tamas Dolowschiak | Zendy; Sandra Y. Wotzka | Zendy; Jette Lengefeld | Zendy; Emma Slack | Zendy; Andrew J. Grant | Zendy; Martin Ackermann | Zendy; WolfDietrich Hardt | Zendy

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Cecum Lymph Node Dendritic Cells Harbor Slow-Growing Bacteria Phenotypically Tolerant to Antibiotic Treatment

Author(s) -

Patrick Kaiser,

Roland R. Regoes,

Tamas Dolowschiak,

Sandra Y. Wotzka,

Jette Lengefeld,

Emma Slack,

Andrew J. Grant,

Martin Ackermann,

WolfDietrich Hardt

Publication year - 2014

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001793

Subject(s) - biology , microbiology and biotechnology , antibiotics , multidrug tolerance , bacteria , ex vivo , in vivo , ciprofloxacin , spleen , lymph , immunity , cecum , immunology , immune system , biofilm , medicine , ecology , genetics , psychiatry

Salmonella bacteria can tolerate antibiotics by adopting a slow-growing “persister” state that hides in host dendritic cells and can re-initiate infection after treatment ends. This can be avoided by supplementing antibiotic treatment with stimulants of innate immunity.

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