Open AccessConservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits
Author(s) -
Joost M. Woltering,
Daan Noordermeer,
Marion Leleu,
Denis Duboule
Publication year - 2014
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001773
Subject(s) - hox gene , biology , zebrafish , tetrapod (structure) , evolutionary biology , genetics , homeobox , chromatin , vertebrate , gene , transcription factor , paleontology
During development, expression of the Hoxa and Hoxd genes in zebrafish fins and mouse limbs are regulated via a conserved chromatin structure. However, zebrafish lack certain regulatory elements required to produce digits, revealing that radials—the fin's bony elements—are likely not homologous to tetrapod digits.
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