The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity
Author(s) -
Anissa Kempf,
Bjoern Tews,
Michael E. Arzt,
Oliver Weinmann,
Franz J. Obermair,
Vincent Pernet,
Marta Zagrebelsky,
Andrea Delekate,
Cristina Iobbi,
Ajmal Zemmar,
Zorica Ristic,
Miriam Gullo,
Peter Spies,
Dana A. Dodd,
Daniel Gygax,
Martin Körte,
Martin E. Schwab
Publication year - 2014
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001763
Subject(s) - biology , microbiology and biotechnology , synaptic plasticity , long term potentiation , neuroscience , signal transduction , g protein coupled receptor , receptor , sphingolipid , neurite , biochemistry , in vitro
This study identifies a GPCR, S1PR2, as a receptor for the Nogo-A-Δ20 domain of the membrane protein Nogo-A, which inhibits neuronal growth and synaptic plasticity.
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