A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo | Zendy

Klaus Heger | Zendy; Kaat Fierens | Zendy; J. Christoph Vahl | Zendy; Attila Aszódi | Zendy; Katrin Peschke | Zendy; Dominik Schenten | Zendy; Hamida Hammad | Zendy; Rudi Beyaert | Zendy; Dieter Saur | Zendy; Geert Loo | Zendy; Axel Roers | Zendy; Bart N. Lambrecht | Zendy; Mirjam Kool | Zendy; Marc SchmidtSupprian | Zendy

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A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo

Author(s) -

Klaus Heger,

Kaat Fierens,

J. Christoph Vahl,

Attila Aszódi,

Katrin Peschke,

Dominik Schenten,

Hamida Hammad,

Rudi Beyaert,

Dieter Saur,

Geert Loo,

Axel Roers,

Bart N. Lambrecht,

Mirjam Kool,

Marc SchmidtSupprian

Publication year - 2014

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001762

Subject(s) - degranulation , immunology , mast cell , inflammation , biology , immunoglobulin e , in vivo , pathogenesis , allergy , receptor , antibody , biochemistry , microbiology and biotechnology

Mast cells, best known as effector cells in pathogenic immunoglobulin-mediated responses, can sense a variety of “danger” signals; if manipulated to enhance their resulting inflammatory responses, they also exacerbate inflammatory diseases such as arthritis and lung inflammation.

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