Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover | Zendy

Shoujun Huang | Zendy; Zhao Zhang | Zendy; Chunxia Zhang | Zendy; Xiangdong Lv | Zendy; Xiu-Deng Zheng | Zendy; Zhenping Chen | Zendy; Li Sun | Zendy; Hailong Wang | Zendy; Yuanxiang Zhu | Zendy; Jing Zhang | Zendy; Shuyan Yang | Zendy; Yi Lu | Zendy; Qinmiao Sun | Zendy; Yi Tao | Zendy; Feng Liu | Zendy; Yun Zhao | Zendy; Dahua Chen | Zendy

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Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover

Author(s) -

Shoujun Huang,

Zhao Zhang,

Chunxia Zhang,

Xiangdong Lv,

Xiu-Deng Zheng,

Zhenping Chen,

Li Sun,

Hailong Wang,

Yuanxiang Zhu,

Jing Zhang,

Shuyan Yang,

Yi Lu,

Qinmiao Sun,

Yi Tao,

Feng Liu,

Yun Zhao,

Dahua Chen

Publication year - 2013

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001721

Subject(s) - smoothened , patched , hedgehog , ubiquitin ligase , biology , hedgehog signaling pathway , microbiology and biotechnology , signal transduction , sonic hedgehog , ubiquitin , gli1 , genetics , gene

Protein turnover of Patched, the Hedgehog receptor and key negative regulator of Hedgehog signaling, is controlled by the ubiquitin E3 ligase, Smurf, in a manner that depends on activation of signal transducer, Smoothened.

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