Open AccessRole of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy
Author(s) -
Jonathan Zirin,
Joppe Nieuwenhuis,
Norbert Perrimon
Publication year - 2013
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001708
Subject(s) - autophagy , atg8 , glycogen , biology , myopathy , lysosome , microbiology and biotechnology , glycogen synthase , chloroquine , bafilomycin , glycogen debranching enzyme , biochemistry , genetics , enzyme , immunology , apoptosis , malaria
A novel Drosophila model system of chloroquine myopathy reveals how glycogen is targeted to the lysosome and what the significance of this process is for muscle cells.
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