N-WASP Is Essential for the Negative Regulation of B Cell Receptor Signaling | Zendy

Chaohong Liu | Zendy; Xiaoming Bai | Zendy; Junfeng Wu | Zendy; Shruti Sharma | Zendy; Arpita Upadhyaya | Zendy; Carin Dahlberg | Zendy; Lisa S. Westerberg | Zendy; Scott B. Snapper | Zendy; Xiaodong Zhao | Zendy; Wenxia Song | Zendy

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N-WASP Is Essential for the Negative Regulation of B Cell Receptor Signaling

Author(s) -

Chaohong Liu,

Xiaoming Bai,

Junfeng Wu,

Shruti Sharma,

Arpita Upadhyaya,

Carin Dahlberg,

Lisa S. Westerberg,

Scott B. Snapper,

Xiaodong Zhao,

Wenxia Song

Publication year - 2013

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001704

Subject(s) - biology , wiskott–aldrich syndrome protein , microbiology and biotechnology , signal transduction , breakpoint cluster region , b cell receptor , cell signaling , internalization , b cell , receptor , cell , immunology , actin cytoskeleton , cytoskeleton , antibody , biochemistry

A cell biology study using conditional gene knockout mouse models reveals a novel mechanism by which the actin cytoskeleton negatively regulates the signal transduction of the B cell antigen receptor.

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