Functional Brachyury Binding Sites Establish a Temporal Read-out of Gene Expression in the Ciona Notochord | Zendy

Lavanya Katikala | Zendy; Hitoshi Aihara | Zendy; Yale J. Passamaneck | Zendy; Stefan Gazdoiu | Zendy; Diana S. JoséEdwards | Zendy; Jamie E. Kugler | Zendy; Izumi OdaIshii | Zendy; Janice H. Imai | Zendy; Yutaka Nibu | Zendy; Anna Di Gregorio | Zendy

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Functional Brachyury Binding Sites Establish a Temporal Read-out of Gene Expression in the Ciona Notochord

Author(s) -

Lavanya Katikala,

Hitoshi Aihara,

Yale J. Passamaneck,

Stefan Gazdoiu,

Diana S. JoséEdwards,

Jamie E. Kugler,

Izumi OdaIshii,

Janice H. Imai,

Yutaka Nibu,

Anna Di Gregorio

Publication year - 2013

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001697

Subject(s) - brachyury , chordate , notochord , ciona , biology , deuterostome , ciona intestinalis , bilateria , microarray analysis techniques , gene regulatory network , transcription factor , genetics , computational biology , enhancer , regulation of gene expression , mesoderm , gene , microbiology and biotechnology , gene expression , embryonic stem cell , vertebrate , phylogenetics , embryogenesis

During notochord formation in chordate embryos, the transcription factor Brachyury employs different regulatory strategies to ensure the sequential activation of downstream genes and thereby the deployment of a specific developmental program at the right time and place.

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