Open AccessFitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B
Author(s) -
Benjamin Vincent,
Alex K. Lancaster,
Ruth ScherzShouval,
Luke Whitesell,
Susan Lindquist
Publication year - 2013
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001692
Subject(s) - biology , drug resistance , amphotericin b , phenotype , experimental evolution , candida albicans , resistance (ecology) , antibiotic resistance , evolutionary dynamics , genetics , microbiology and biotechnology , antibiotics , gene , antifungal , population , ecology , demography , sociology
The rarity of clinical drug resistance to the antifungal amphotericin B is explained by the extreme costs that resistance mutations impose upon stress responses and virulence factors.
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