Open AccessDeciphering the Structural Basis of Eukaryotic Protein Kinase Regulation
Author(s) -
Hiruy S. Meharena,
Philip Chang,
Malik M. Keshwani,
Krishnadev Oruganty,
Aishwarya Nene,
Natarajan Kannan,
Susan S. Taylor,
Alexandr P. Kornev
Publication year - 2013
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001680
Subject(s) - kinome , biology , mutagenesis , kinase , computational biology , protein kinase a , phosphorylation , protein structure , biochemistry , microbiology and biotechnology , mutation , gene
Biochemical and structural analysis of two features of kinase structure, the “R-spine” and “Shell,” afford a detailed insight into the regulation of eukaryotic protein kinases.
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