eIF4EBP3L Acts as a Gatekeeper of TORC1 In Activity-Dependent Muscle Growth by Specifically Regulating Mef2ca Translational Initiation | Zendy

Orli Yogev | Zendy; Victoria C. Williams | Zendy; Yaniv Hinits | Zendy; Simon M. Hughes | Zendy

Open Access

eIF4EBP3L Acts as a Gatekeeper of TORC1 In Activity-Dependent Muscle Growth by Specifically Regulating Mef2ca Translational Initiation

Author(s) -

Orli Yogev,

Victoria C. Williams,

Yaniv Hinits,

Simon M. Hughes

Publication year - 2013

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001679

Subject(s) - biology , myosin , mef2c , myod , polysome , microbiology and biotechnology , muscle hypertrophy , myofibril , myostatin , protein degradation , mef2 , protein turnover , protein biosynthesis , zebrafish , medicine , myocyte , endocrinology , transcription factor , biochemistry , myogenesis , rna , ribosome , enhancer , gene

Muscle activity promotes muscle growth through the TOR-4EBP pathway by controlling the translation of specific mRNAs, including Mef2ca, a muscle transcription factor required for normal growth.

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