Open AccessDesign Principles of the Yeast G1/S Switch
Author(s) -
Xiaojing Yang,
KaiYeung Lau,
Volkan Sevi̇m,
Chao Tang
Publication year - 2013
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001673
Subject(s) - biology , microbiology and biotechnology , cyclin dependent kinase , cyclin dependent kinase 1 , cell cycle , kinase , genetics , cell
Single-cell microscopy and computational modeling offer novel mechanistic insight into the G1/S switch that initiates DNA replication in budding yeast, revealing a Clb5/6-Cdk1 and Sic1 feedback loop and new rules of biochemical circuit design.
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