Open AccessThe CK2 Kinase Stabilizes CLOCK and Represses Its Activity in the Drosophila Circadian Oscillator
Author(s) -
Áron Szabó,
Christian Papin,
Daniela Zorn,
Prishila Ponien,
Frank Weber,
Thomas Raabe,
François Rouyer
Publication year - 2013
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001645
Subject(s) - biology , circadian clock , timeless , protein subunit , microbiology and biotechnology , post translational regulation , casein kinase 1 , phosphorylation , protein kinase a , circadian rhythm , genetics , gene , neuroscience
The CK2 kinase plays diverse roles in the Drosophila circadian clock by controlling stability of the CLOCK transcription factor itself, besides its known role in degrading CLOCK repressors.
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