Mapping Differentiation under Mixed Culture Conditions Reveals a Tunable Continuum of T Cell Fates | Zendy

Yaron E. Antebi | Zendy; Shlomit Reich-Zeliger | Zendy; Yuval Hart | Zendy; Avi Mayo | Zendy; Inbal Eizenberg | Zendy; Jacob Rimer | Zendy; Prabhakar Putheti | Zendy; Dana Pe’er | Zendy; Nir Friedman | Zendy

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Mapping Differentiation under Mixed Culture Conditions Reveals a Tunable Continuum of T Cell Fates

Author(s) -

Yaron E. Antebi,

Shlomit Reich-Zeliger,

Yuval Hart,

Avi Mayo,

Inbal Eizenberg,

Jacob Rimer,

Prabhakar Putheti,

Dana Pe’er,

Nir Friedman

Publication year - 2013

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001616

Subject(s) - biology , phenotype , transcription factor , microbiology and biotechnology , lineage (genetic) , cellular differentiation , gene regulatory network , gata3 , cell , lineage markers , regulation of gene expression , gene expression , gene , cell fate determination , genetics

An experimental and theoretical study of T cell differentiation in response to mixed-input conditions reveals that cells can tune between Th1 and Th2 states through a continuum of mixed phenotypes.

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