Self-Renewal of Single Mouse Hematopoietic Stem Cells Is Reduced by JAK2V617F Without Compromising Progenitor Cell Expansion | Zendy

David G. Kent | Zendy; Juan Li | Zendy; Hinal Tanna | Zendy; Juergen Fink | Zendy; Kristina Kirschner | Zendy; Dean C. Pask | Zendy; Yvonne Silber | Zendy; Tina L. Hamilton | Zendy; Rachel Sneade | Zendy; Benjamin D. Simons | Zendy; Anthony R. Green | Zendy

Open Access

Self-Renewal of Single Mouse Hematopoietic Stem Cells Is Reduced by JAK2V617F Without Compromising Progenitor Cell Expansion

Author(s) -

David G. Kent,

Juan Li,

Hinal Tanna,

Juergen Fink,

Kristina Kirschner,

Dean C. Pask,

Yvonne Silber,

Tina L. Hamilton,

Rachel Sneade,

Benjamin D. Simons,

Anthony R. Green

Publication year - 2013

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001576

Subject(s) - biology , stem cell , progenitor cell , haematopoiesis , transplantation , microbiology and biotechnology , carcinogenesis , hematopoietic stem cell , cancer research , proto oncogene proteins c kit , tyrosine kinase , immunology , genetics , stem cell factor , signal transduction , cancer , medicine

In this study, single cell assays and mathematical modeling demonstrate that a single oncogenic point mutation can negatively affect hematopoietic stem cells while leaving progenitor cell expansion intact.

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