Open AccessReduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function
Author(s) -
Ryo Suzuki,
Heather A. Ferris,
Melissa J. Chee,
Eleftheria Maratos–Flier,
C. Ronald Kahn
Publication year - 2013
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001532
Subject(s) - long term potentiation , biology , endocrinology , medicine , cholesterol , neural facilitation , type 2 diabetes , neurotransmission , haploinsufficiency , diabetes mellitus , neuroscience , phenotype , gene , genetics , receptor
A conditional knockout of SCAP in the mouse brain identifies impaired cholesterol synthesis as a potential link between diabetes and altered brain function.
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