Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival | Zendy

Danièl Thomas | Zendy; Jason A. Powell | Zendy; Benjamin D. Green | Zendy; Emma F. Barry | Zendy; Yuefang Ma | Zendy; Joanna M. Woodcock | Zendy; Stephen Fitter | Zendy; Andrew C.W. Zannettino | Zendy; Stuart M. Pitson | Zendy; Timothy P. Hughes | Zendy; Angel F. López | Zendy; Peter R. Shepherd | Zendy; Andrew H. Wei | Zendy; Paul G. Ekert | Zendy; Mark A. Guthridge | Zendy

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Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival

Author(s) -

Danièl Thomas,

Jason A. Powell,

Benjamin D. Green,

Emma F. Barry,

Yuefang Ma,

Joanna M. Woodcock,

Stephen Fitter,

Andrew C.W. Zannettino,

Stuart M. Pitson,

Timothy P. Hughes,

Angel F. López,

Peter R. Shepherd,

Andrew H. Wei,

Paul G. Ekert,

Mark A. Guthridge

Publication year - 2013

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001515

Subject(s) - biology , microbiology and biotechnology , akt1 , protein kinase b , pi3k/akt/mtor pathway , cancer research , phosphorylation , signal transduction

The protein kinase activity of PI3K phosphorylates specific serine residues in growth factor receptors to promote cell survival; these events are constitutively activated in some leukemias.

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