Secretion and Signaling Activities of Lipoprotein-Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals | Zendy

Wilhelm Palm | Zendy; Marta M. Swierczynska | Zendy; V.K. Krishna Kumari | Zendy; Monika EhrhartBornstein | Zendy; Stefan R. Bornstein | Zendy; Suzanne Eaton | Zendy

Open Access

Secretion and Signaling Activities of Lipoprotein-Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals

Author(s) -

Wilhelm Palm,

Marta M. Swierczynska,

V.K. Krishna Kumari,

Monika EhrhartBornstein,

Stefan R. Bornstein,

Suzanne Eaton

Publication year - 2013

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001505

Subject(s) - biology , hedgehog , hedgehog signaling pathway , microbiology and biotechnology , sterol , smoothened , sonic hedgehog , secretion , lipoprotein , imaginal disc , signal transduction , genetics , gene , biochemistry , cholesterol , phenotype

We identify two distinct Hh secretion forms with complementary signaling activities produced in both mammals and flies: one sterol-modified and lipoprotein-associated, and another lacking sterol modification.

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