Open AccessThe Cellular and Molecular Basis of Bitter Tastant-Induced Bronchodilation
Author(s) -
Cheng–Hai Zhang,
Lawrence M. Lifshitz,
Karl Uy,
Mitsuo Ikebe,
Kevin E. Fogarty,
Ronghua ZhuGe
Publication year - 2013
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001501
Subject(s) - bronchodilation , biology , microbiology and biotechnology , phospholipase c , receptor , g protein coupled receptor , bronchodilatation , intracellular , biophysics , signal transduction , biochemistry , bronchodilator , immunology , asthma
Bitter tastants can activate bitter taste receptors on constricted smooth muscle cells to inhibit L-type calcium channels and induce bronchodilation.
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