Mechanistic Insights Revealed by the Crystal Structure of a Histidine Kinase with Signal Transducer and Sensor Domains | Zendy

Chen Wang | Zendy; Jiayan Sang | Zendy; Jiawei Wang | Zendy; Ming-yan Su | Zendy; Jennifer S. Downey | Zendy; Qinggan Wu | Zendy; Shida Wang | Zendy; Yongfei Cai | Zendy; Xiaozheng Xu | Zendy; Jun Wu | Zendy; Dilani B. Senadheera | Zendy; Dennis G. Cvitkovitch | Zendy; Lin Chen | Zendy; Steven D. Goodman | Zendy; Aidong Han | Zendy

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Mechanistic Insights Revealed by the Crystal Structure of a Histidine Kinase with Signal Transducer and Sensor Domains

Author(s) -

Chen Wang,

Jiayan Sang,

Jiawei Wang,

Ming-yan Su,

Jennifer S. Downey,

Qinggan Wu,

Shida Wang,

Yongfei Cai,

Xiaozheng Xu,

Jun Wu,

Dilani B. Senadheera,

Dennis G. Cvitkovitch,

Lin Chen,

Steven D. Goodman,

Aidong Han

Publication year - 2013

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001493

Subject(s) - histidine kinase , response regulator , biology , biophysics , phosphatase , hamp domain , phosphorylation , histidine , dimer , kinase , biochemistry , crystallography , microbiology and biotechnology , binding site , nuclear magnetic resonance , chemistry , physics , amino acid , binding domain , gene , mutant

A crystal structure reveals an elegant mechanistic switch whereby helical bending and catalytic domain rotation allow self-activation of a histidine kinase during a bacterial stress response.

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