ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer | Zendy

Maria Kalyuga | Zendy; David GallegoOrtega | Zendy; Heather Lee | Zendy; Daniel Roden | Zendy; Mark J. Cowley | Zendy; C. Elizabeth Caldon | Zendy; Andrew Stone | Zendy; Stephanie L. Allerdice | Zendy; Fátima ValdésMora | Zendy; Rosalind Launchbury | Zendy; Aaron L. Statham | Zendy; Nicola J. Armstrong | Zendy; M. Chehani Alles | Zendy; Adelaide I.J. Young | Zendy; Andrea Egger | Zendy; Wendy W.Y. Au | Zendy; Catherine Piggin | Zendy; Cara J. Evans | Zendy; Anita Ledger | Zendy; Tilman Brummer | Zendy; Samantha R. Oakes | Zendy; Warren Kaplan | Zendy; Julia M.W. Gee | Zendy; Robert I. Nicholson | Zendy; Robert L. Sutherland | Zendy; Alexander Swarbrick | Zendy; Matthew J. Naylor | Zendy; Susan J. Clark | Zendy; Jason S. Carroll | Zendy; Christopher J. Ormandy | Zendy

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ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer

Author(s) -

Maria Kalyuga,

David GallegoOrtega,

Heather Lee,

Daniel Roden,

Mark J. Cowley,

C. Elizabeth Caldon,

Andrew Stone,

Stephanie L. Allerdice,

Fátima ValdésMora,

Rosalind Launchbury,

Aaron L. Statham,

Nicola J. Armstrong,

M. Chehani Alles,

Adelaide I.J. Young,

Andrea Egger,

Wendy W.Y. Au,

Catherine Piggin,

Cara J. Evans,

Anita Ledger,

Tilman Brummer,

Samantha R. Oakes,

Warren Kaplan,

Julia M.W. Gee,

Robert I. Nicholson,

Robert L. Sutherland,

Alexander Swarbrick,

Matthew J. Naylor,

Susan J. Clark,

Jason S. Carroll,

Christopher J. Ormandy

Publication year - 2012

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001461

Subject(s) - biology , breast cancer , tamoxifen , estrogen receptor , antiestrogen , foxa1 , cancer research , estrogen , gene knockdown , medicine , chromatin immunoprecipitation , estrogen receptor alpha , cancer , endocrinology , gene expression , genetics , gene , promoter

The transcription factor ELF5 is responsible for gene expression patterning underlying molecular subtypes of breast cancer and may mediate acquired resistance to anti-estrogen therapy.

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