Open AccessThe Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility
Author(s) -
Carolin Seuring,
Jason Greenwald,
Christian Wasmer,
Roger Wepf,
Sven J. Saupe,
Beat H. Meier,
Roland Riek
Publication year - 2012
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001451
Subject(s) - podospora anserina , biology , cytoplasm , programmed cell death , amyloid (mycology) , microbiology and biotechnology , biophysics , membrane , biochemistry , apoptosis , gene , mutant , botany
A nontoxic functional prion activates toxicity in the HET-S/HET-s fungal heterokaryon incompatibility system by converting HET-S into a cytotoxic membrane protein.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom