Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides | Zendy

Nuria IzquierdoUseros | Zendy; Maier Lorizate | Zendy; María C. Puertas | Zendy; Maria T. RodriguezPlata | Zendy; Nadine Zangger | Zendy; Elina Erikson | Zendy; María Pino | Zendy; Itziar Erkizia | Zendy; Bärbel Glass | Zendy; Bonaventura Clotet | Zendy; Oliver T. Keppler | Zendy; Amalio Telenti | Zendy; HansGeorg Kräusslich | Zendy; Javier MartínezPicado | Zendy

Open Access

Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

Author(s) -

Nuria IzquierdoUseros,

Maier Lorizate,

María C. Puertas,

Maria T. RodriguezPlata,

Nadine Zangger,

Elina Erikson,

María Pino,

Itziar Erkizia,

Bärbel Glass,

Bonaventura Clotet,

Oliver T. Keppler,

Amalio Telenti,

HansGeorg Kräusslich,

Javier MartínezPicado

Publication year - 2012

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001448

Subject(s) - biology , dc sign , siglec , c type lectin , microbiology and biotechnology , glycoprotein , membrane glycoproteins , dendritic cell , sialic acid , lectin , virology , antigen , immunology , biochemistry

The novel dendritic cell receptor Siglec-1 binds sialyllactose moieties on HIV-1 membrane gangliosides, thereby enhancing HIV-1 transinfection.

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