Open AccessStructural Mechanism of ER Retrieval of MHC Class I by Cowpox
Author(s) -
William H. McCoy,
Xiaoli Wang,
Wayne M. Yokoyama,
Ted H. Hansen,
Daved H. Fremont
Publication year - 2012
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001432
Subject(s) - biology , mhc class i , major histocompatibility complex , cowpox virus , antigen presentation , endoplasmic reticulum , microbiology and biotechnology , cowpox , antigen , biochemistry , immune system , vaccinia , t cell , genetics , gene , recombinant dna
Structure-function studies reveal how a poxvirus protein blocks cell surface display of MHC class I by exploiting cellular ER retrieval processes.
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