Open AccessGeneration of Functional Blood Vessels from a Single c-kit+ Adult Vascular Endothelial Stem Cell
Author(s) -
Shentong Fang,
Jing Wei,
Nalle Pentinmikko,
H. Lein,
Petri Salvén
Publication year - 2012
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001407
Subject(s) - angiogenesis , biology , cd31 , endothelial stem cell , stem cell , endothelium , microbiology and biotechnology , neovascularization , blood vessel , endoglin , immunology , cancer research , pathology , cd34 , in vitro , endocrinology , genetics , medicine
Adult vascular endothelial stem cells are shown to reside in the blood vessel wall endothelium. When isolated, these cells are capable of clonal expansion and generate functional blood vessels in vivo.
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