Independent Regulation of Basal Neurotransmitter Release Efficacy by Variable Ca2+ Influx and Bouton Size at Small Central Synapses | Zendy

Yaroslav S. Ermolyuk | Zendy; Felicity G. Alder | Zendy; Christian Henneberger | Zendy; Dmitri A. Rusakov | Zendy; Dimitri M. Kullmann | Zendy; Kirill E. Volynski | Zendy

Open Access

Independent Regulation of Basal Neurotransmitter Release Efficacy by Variable Ca2+ Influx and Bouton Size at Small Central Synapses

Author(s) -

Yaroslav S. Ermolyuk,

Felicity G. Alder,

Christian Henneberger,

Dmitri A. Rusakov,

Dimitri M. Kullmann,

Kirill E. Volynski

Publication year - 2012

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001396

Subject(s) - biology , exocytosis , neurotransmitter , synaptic vesicle , vesicle , active zone , hippocampal formation , autoreceptor , neuroscience , neurotransmission , synapse , biophysics , central nervous system , serotonin , biochemistry , receptor , membrane

Concurrent imaging of vesicular release and calcium dynamics in small presynaptic boutons shows that the fusion probability of readily releasable vesicles is a major determinant of the overall variability in release probability.

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