Stat5 Signaling Specifies Basal versus Stress Erythropoietic Responses through Distinct Binary and Graded Dynamic Modalities | Zendy

Ermelinda Porpiglia | Zendy; Daniel Hidalgo | Zendy; Miroslav Koulnis | Zendy; Abraham R. Tzafriri | Zendy; Merav Socolovsky | Zendy

Open Access

Stat5 Signaling Specifies Basal versus Stress Erythropoietic Responses through Distinct Binary and Graded Dynamic Modalities

Author(s) -

Ermelinda Porpiglia,

Daniel Hidalgo,

Miroslav Koulnis,

Abraham R. Tzafriri,

Merav Socolovsky

Publication year - 2012

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001383

Subject(s) - erythropoietin receptor , biology , erythroblast , erythropoiesis , erythropoietin , stat5 , phosphorylation , signal transduction , microbiology and biotechnology , cancer research , endocrinology , medicine , haematopoiesis , stem cell , anemia

Stat5 signaling in erythroblasts can assume either a binary, low-intensity form, essential for basal erythropoiesis, or a graded, high-intensity response, restricted to early erythroblasts and to erythropoietic stress.

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