LAB-1 Targets PP1 and Restricts Aurora B Kinase upon Entrance into Meiosis to Promote Sister Chromatid Cohesion | Zendy

Yonatan B. Tzur | Zendy; Carlos Egydio de Carvalho | Zendy; Saravanapriah Nadarajan | Zendy; Ivo van Bostelen | Zendy; Yanjie Gu | Zendy; Diana S. Chu | Zendy; Iain M. Cheeseman | Zendy; Mónica P. Colaiácovo | Zendy

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LAB-1 Targets PP1 and Restricts Aurora B Kinase upon Entrance into Meiosis to Promote Sister Chromatid Cohesion

Author(s) -

Yonatan B. Tzur,

Carlos Egydio de Carvalho,

Saravanapriah Nadarajan,

Ivo van Bostelen,

Yanjie Gu,

Diana S. Chu,

Iain M. Cheeseman,

Mónica P. Colaiácovo

Publication year - 2012

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001378

Subject(s) - establishment of sister chromatid cohesion , cohesin , sister chromatids , biology , chromatid , meiosis , prophase , genetics , microbiology and biotechnology , chromosome segregation , homologous chromosome , separase , chromosome , gene

At the onset of the first meiotic division, the protein LAB-1 recruits the PP1 phosphatase to cohesion complexes, preventing Aurora B kinase from targeting cohesins for degradation prematurely and thereby ensuring proper progression of meiotic events in C. elegans .

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