The Germinal Center Kinase TNIK Is Required for Canonical NF-κB and JNK Signaling in B-Cells by the EBV Oncoprotein LMP1 and the CD40 Receptor | Zendy

Anna Shkoda | Zendy; Jennifer A. Town | Zendy; Janine Griese | Zendy; Michael Romio | Zendy; Hakan Sarioglu | Zendy; Thomas Knöfel | Zendy; Fabian Giehler | Zendy; Arnd Kieser | Zendy

Open Access

The Germinal Center Kinase TNIK Is Required for Canonical NF-κB and JNK Signaling in B-Cells by the EBV Oncoprotein LMP1 and the CD40 Receptor

Author(s) -

Anna Shkoda,

Jennifer A. Town,

Janine Griese,

Michael Romio,

Hakan Sarioglu,

Thomas Knöfel,

Fabian Giehler,

Arnd Kieser

Publication year - 2012

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001376

Subject(s) - traf2 , biology , cancer research , microbiology and biotechnology , map kinase kinase kinase , iκb kinase , signal transduction , kinase , nf κb , protein kinase a , tumor necrosis factor alpha , immunology , tumor necrosis factor receptor

TNIK has an important function in physiological activation and viral transformation of human B-cells by interacting with the TRAF6 adapter complex and mediating NF-κB and JNK signal transduction.

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