Open AccessHaemodynamics-Driven Developmental Pruning of Brain Vasculature in Zebrafish
Author(s) -
Qi Chen,
Luan Jiang,
Chun Li,
Dan Hu,
Ji-wen Bu,
David Cai,
Jiu-lin Du
Publication year - 2012
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001374
Subject(s) - biology , zebrafish , pruning , blood flow , midbrain , blood vessel , hemodynamics , neuroscience , anatomy , cerebral circulation , central nervous system , medicine , endocrinology , botany , biochemistry , gene
This in vivo time-lapse imaging study in zebrafish reveals how changes to brain blood flow drive vessel pruning via endothelial cell migration, and how pruning leads to the simplification of the brain vasculature during development.
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