An Autism-Associated Variant of Epac2 Reveals a Role for Ras/Epac2 Signaling in Controlling Basal Dendrite Maintenance in Mice | Zendy

Deepak P. Srivastava | Zendy; Kevin M. Woolfrey | Zendy; Kelly A. Jones | Zendy; Charles T. Anderson | Zendy; Katharine R. Smith | Zendy; Theron A. Russell | Zendy; Hyerin Lee | Zendy; Marina V. Yasvoina | Zendy; David L. Wokosin | Zendy; P. Hande Özdi̇nler | Zendy; Gordon M. Shepherd | Zendy; Peter Penzes | Zendy

Open Access

An Autism-Associated Variant of Epac2 Reveals a Role for Ras/Epac2 Signaling in Controlling Basal Dendrite Maintenance in Mice

Author(s) -

Deepak P. Srivastava,

Kevin M. Woolfrey,

Kelly A. Jones,

Charles T. Anderson,

Katharine R. Smith,

Theron A. Russell,

Hyerin Lee,

Marina V. Yasvoina,

David L. Wokosin,

P. Hande Özdi̇nler,

Gordon M. Shepherd,

Peter Penzes

Publication year - 2012

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001350

Subject(s) - biology , guanine nucleotide exchange factor , microbiology and biotechnology , dendritic spine , dendrite (mathematics) , neuroscience , apical dendrite , hippocampal formation , signal transduction , cerebral cortex , geometry , mathematics

Epac2 disruption impairs basal (but not apical) dendrite complexity in cortical neurons, and an autism-associated mutation in Epac2 implicates a Ras/Epac2 signaling pathway in the active maintenance of basal dendritic arbors.

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