The Core Apoptotic Executioner Proteins CED-3 and CED-4 Promote Initiation of Neuronal Regeneration in Caenorhabditis elegans | Zendy

Bérangère PinanLucarré | Zendy; Christopher V. Gabel | Zendy; Christopher P. Reina | Zendy; S. Elizabeth Hulme | Zendy; Sergey S. Shevkoplyas | Zendy; R. Daniel Slone | Zendy; Jian Xue | Zendy; Yujie Qiao | Zendy; Sarah Weisberg | Zendy; Kevin Roodhouse | Zendy; Lin Sun | Zendy; George M. Whitesides | Zendy; Aravinthan D. T. Samuel | Zendy; Monica Driscoll | Zendy

Open Access

The Core Apoptotic Executioner Proteins CED-3 and CED-4 Promote Initiation of Neuronal Regeneration in Caenorhabditis elegans

Author(s) -

Bérangère PinanLucarré,

Christopher V. Gabel,

Christopher P. Reina,

S. Elizabeth Hulme,

Sergey S. Shevkoplyas,

R. Daniel Slone,

Jian Xue,

Yujie Qiao,

Sarah Weisberg,

Kevin Roodhouse,

Lin Sun,

George M. Whitesides,

Aravinthan D. T. Samuel,

Monica Driscoll

Publication year - 2012

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001331

Subject(s) - biology , microbiology and biotechnology , caenorhabditis elegans , regeneration (biology) , calcium signaling , endoplasmic reticulum , signal transduction , genetics , gene

Laser severing of individual axons in the nematode Caenorhabditis elegans revealed that the apoptotic executioner caspase CED-3 and its regulator CED-4/Apaf-1 play an unexpected beneficial role in promoting axonal regeneration.

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