Open AccessLipids in HIV's Envelope Help the Virus to Spread
Author(s) -
Caitlin Sedwick
Publication year - 2012
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001316
Subject(s) - biology , immune system , virus , virology , viral envelope , microbiology and biotechnology , lipid raft , immunology , signal transduction
An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes.
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