Hormonal Signal Amplification Mediates Environmental Conditions during Development and Controls an Irreversible Commitment to Adulthood | Zendy

Oren N. Schaedel | Zendy; Birgit Gerisch | Zendy; Adam Antebi | Zendy; Paul W. Sternberg | Zendy

Open Access

Hormonal Signal Amplification Mediates Environmental Conditions during Development and Controls an Irreversible Commitment to Adulthood

Author(s) -

Oren N. Schaedel,

Birgit Gerisch,

Adam Antebi,

Paul W. Sternberg

Publication year - 2012

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001306

Subject(s) - biology , caenorhabditis elegans , mechanism (biology) , microbiology and biotechnology , cell fate determination , developmental biology , hormone , epidermis (zoology) , organism , nuclear receptor , disorders of sex development , diapause , neuroscience , evolutionary biology , genetics , gene , ecology , endocrinology , transcription factor , anatomy , philosophy , epistemology , larva

A dual mechanism regulates the developmental fate choice in C. elegans in response to population density: variation of the threshold of DA hormone required to commit to a certain fate and a positive feedback loop that amplifies this hormonal signal to ensure an organism-wide developmental fate choice.

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