Maternal xNorrin, a Canonical Wnt Signaling Agonist and TGF-β Antagonist, Controls Early Neuroectoderm Specification in Xenopus | Zendy

Suhong Xu | Zendy; Feng Cheng | Zendy; Juan Liang | Zendy; Wei Wu | Zendy; Jian Zhang | Zendy

Open Access

Maternal xNorrin, a Canonical Wnt Signaling Agonist and TGF-β Antagonist, Controls Early Neuroectoderm Specification in Xenopus

Author(s) -

Suhong Xu,

Feng Cheng,

Juan Liang,

Wei Wu,

Jian Zhang

Publication year - 2012

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001286

Subject(s) - neuroectoderm , biology , wnt signaling pathway , noggin , xenopus , chordin , ectoderm , microbiology and biotechnology , mesoderm , nodal , nodal signaling , neural development , genetics , gastrulation , endocrinology , signal transduction , embryogenesis , embryo , bone morphogenetic protein , embryonic stem cell , gene

Xenopus maternal Norrin, which activates Wnt signaling but inhibits TGF-β family molecules, is essential for neuroectoderm formation. Loss of TGF-β inhibition in Norrin may contribute to the development of Norrie disease.

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