Open AccessConvergent Evolution of Escape from Hepaciviral Antagonism in Primates
Author(s) -
Maulik Patel,
Yueh–Ming Loo,
Stacy M. Horner,
Michael Gale,
Harmit S. Malik
Publication year - 2012
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001282
Subject(s) - biology , virology , ns3 , protease , proteases , innate immune system , viral replication , hepatitis c virus , convergent evolution , antagonism , viral evolution , virus , genetics , immune system , phylogenetics , gene , genome , receptor , enzyme , biochemistry
Escape from antagonism by hepatitis C and related viruses has repeatedly evolved in antiviral factor MAVS via convergent evolution, revealing an ancient history of previous viral encounters in primates.
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