Open AccessHistone Deacetylase Complexes Promote Trinucleotide Repeat Expansions
Author(s) -
Kim Debacker,
Aisling Frizzell,
Olive Gleeson,
Lucy Kirkham-McCarthy,
Tony M. Mertz,
Robert S. Lahue
Publication year - 2012
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001257
Subject(s) - biology , histone deacetylase , hdac3 , trinucleotide repeat expansion , histone , genetics , gene silencing , mutant , microbiology and biotechnology , gene , allele
Genetic analysis in budding yeast and in cultured human astrocytes reveals that specific histone deacetylase complexes accelerate expansion mutations in DNA triplet repeats.
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