Open AccessPulsed Feedback Defers Cellular Differentiation
Author(s) -
Joe H. Levine,
Michelle E. Fontes,
Jonathan Dworkin,
Michael B. Elowitz
Publication year - 2012
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001252
Subject(s) - biology , microbiology and biotechnology , deferral , kinase , cell division , cell cycle , phosphorylation , cell fate determination , positive feedback , negative feedback , cell , signal transduction , regulator , genetics , transcription factor , gene , physics , accounting , engineering , quantum mechanics , voltage , electrical engineering , business
In response to sudden environmental stress, B. subtilis cells can defer sporulation for multiple cell cycles using a pulsed positive feedback loop.
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