Open AccessTwo PI 3-Kinases and One PI 3-Phosphatase Together Establish the Cyclic Waves of Phagosomal PtdIns(3)P Critical for the Degradation of Apoptotic Cells
Author(s) -
Nan Lü,
Qian Shen,
Timothy R. Mahoney,
Lukas J. Neukomm,
Ying Wang,
Zheng Zhou
Publication year - 2012
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001245
Subject(s) - phagosome , microbiology and biotechnology , biology , phosphatase , phosphatidylinositol , autophagy , kinase , pi , dynamin , phosphorylation , phagocytosis , biochemistry , apoptosis , endocytosis , receptor
Cyclic oscillations in the level of phosphatidylinositol 3-phosphate in phagosomes, regulated by two phosphoinositide kinases and one phosphatase, are critical for phagosome maturation and degradation of apoptotic cells.
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