Open AccessUSP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization
Author(s) -
Ruohan Xia,
Hongge Jia,
Junkai Fan,
Yajuan Liu,
Jianhang Jia
Publication year - 2012
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001238
Subject(s) - smoothened , ubiquitin , deubiquitinating enzyme , microbiology and biotechnology , phosphorylation , hedgehog signaling pathway , biology , hedgehog , cyclopamine , signal transduction , immunoprecipitation , endosome , intracellular , biochemistry , gene
Hedgehog regulates the activity of its signal transducer Smoothened by enhancing its interaction with the deubiquitinase USP8, thereby promoting Smoothened translocation to the cell surface and so enhancing Hh signaling.
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