Open AccessCoupled Motions Direct Electrons along Human Microsomal P450 Chains
Author(s) -
Christopher R. Pudney,
B. Khara,
Linus O. Johannissen,
Nigel S. Scrutton
Publication year - 2011
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001222
Subject(s) - electron transfer , flavin group , redox , catalytic cycle , flavin adenine dinucleotide , heme , electron transport chain , cytochrome p450 , förster resonance energy transfer , biophysics , enzyme , chemistry , cofactor , photochemistry , biochemistry , biology , physics , fluorescence , quantum mechanics , organic chemistry
Directional electron transfer through biological redox chains can be achieved by coupling reaction chemistry to conformational changes in individual redox enzymes.
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