Memory Phenotype CD4 T Cells Undergoing Rapid, Nonburst-Like, Cytokine-Driven Proliferation Can Be Distinguished from Antigen-Experienced Memory Cells | Zendy

SouheilAntoine Younes | Zendy; George A. Punkosdy | Zendy; Stéphane Caucheteux | Zendy; Tao Chen | Zendy; Zvi Grossman | Zendy; William E. Paul | Zendy

Open Access

Memory Phenotype CD4 T Cells Undergoing Rapid, Nonburst-Like, Cytokine-Driven Proliferation Can Be Distinguished from Antigen-Experienced Memory Cells

Author(s) -

SouheilAntoine Younes,

George A. Punkosdy,

Stéphane Caucheteux,

Tao Chen,

Zvi Grossman,

William E. Paul

Publication year - 2011

Publication title -

plos biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.127

H-Index - 271

eISSN - 1545-7885

pISSN - 1544-9173

DOI - 10.1371/journal.pbio.1001171

Subject(s) - biology , lymphocytic choriomeningitis , il 2 receptor , population , antigen , interleukin 21 , immunology , microbiology and biotechnology , t cell , immune system , cd8 , demography , sociology

Contrary to the current paradigm that nearly all memory T cells proliferate in response to antigenic stimulation, this paper shows that an important population of CD4 T lymphocytes achieves memory/effector status independent of antigenic stimulation.

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