Open AccessESRRA-C11orf20 Is a Recurrent Gene Fusion in Serous Ovarian Carcinoma
Author(s) -
Julia Salzman,
Robert J. Marinelli,
Peter L. Wang,
Ann E. Green,
Julie S. Nielsen,
Brad H. Nelson,
Charles W. Drescher,
Patrick O. Brown
Publication year - 2011
Publication title -
plos biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.127
H-Index - 271
eISSN - 1545-7885
pISSN - 1544-9173
DOI - 10.1371/journal.pbio.1001156
Subject(s) - biology , ovarian carcinoma , fusion gene , gene , serous fluid , cancer research , ovarian cancer , computational biology , bioinformatics , genetics , cancer , biochemistry
Many ovarian cancers have a chromosomal rearrangement that fuses two neighboring genes, ESRRA and c11orf20. Similar rearrangements may be common, important features of cancer genomes that have largely escaped detection.
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